Influenza A Virus Hemagglutinin Trimerization Completes Monomer Folding and Antigenicity
نویسندگان
چکیده
منابع مشابه
Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity.
Influenza A virus (IAV) remains an important human pathogen largely because of antigenic drift, the rapid emergence of antibody escape mutants that precludes durable vaccination. The most potent neutralizing antibodies interact with cognate epitopes in the globular "head" domain of hemagglutinin (HA), a homotrimeric glycoprotein. The H1 HA possesses five distinct regions defined by a large numb...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.00471-13